Anything placed in between the headstock spindle and the tail stock ram can cause and compound misalignment. Assuming you head and tail stock components are ok, I would:
Check that your HS is secure (in case you have one that rotates).
Your TS is seated and locks properly - you shouldn't be able to move it when locked.
Place two centers that you know to be "true" in your HS and TS and then slide the TS to the HS, lock the TS. When locked, the points of the centers should meet point-to-point. Make your TS locked and your TS center quill is locked (smaller lever near the ram)
If your lathe and centers are "true". It can be anything - bent or loose mandrel, loose fitting bushing, dust or glue inside the tube, dull tools causing you to exert too much shear force against the mandrel (causing it to bend).
I also want to add that I am not a machinist or experienced woodturner; I am sure you will get better advice from those that know much more than I do...and there are plenty. Having said that..do a search on the IAP using key words: "Mandrel Bender". You will see the "heck" I went through and the wise advise that I was given. Needless to say, I don't use a mandrel any more. Some folks can use one without a problem; I cannot. Much success!