From the point of view of safety, a good default assumption is "never sand without a mask" (that goes for wood too - wood dust can be as dangerous as plastic dust, even the species that are generally considered food safe).
I know how to identify some vintage materials by a tiny rub with sandpaper based on the smell - celluloid (true celluloid, that is cellulose nitrate) smells like camphor (mothballs). Celluloid acetate often smells like acetic acid (vinegar). Galalith (a.k.a. casein) smells like hot milk.
The modern materials I normally classify as "can thread (for kitless pens) easily" or "let somebody else have the headache." I can usually guess based on feel if a rod is polyester resin versus urethane resin versus acrylic acetate - but don't know a foolproof way to distinguish them.