Ron,
I've only done a few resin pens, and have yet to do an acrylic pen. However, I had trouble with CA in my resin pens, and someone (elody21?) suggested switching to poly glue. My new technique for poly, which works well for me regardless of whether it is wood or resin, is:
1) drill out the blank
2) clean the inside of the tube well using DNA to make sure there's no dust inside
3) scuff up the tube
4) wipe the tube with DNA to get rid of my hand oils
5) wipe the inside of the blank with a Q-tip that has some water on it (just enough to keep the inside moist)
6) spread poly glue inside the blank with a Q-tip
7) spread poly glue across the outer surface of the tube with a Q-tip
8) breathe on the tube and poly glue, to make sure there's some additional water vapor there
9) slide the tube in the blank
I find that, when I stick to these rules, everything works great. If I start to deviate, that's when I get problems. For example, when I first used poly glue, it didn't work well for me. After asking around on here, I found out poly glue is supposed to foam as it cures; my first set of poly glued blanks never foamed. The foaming is from the interaction of the glue and water; apparently my blanks didn't get enough water when I was working with them back then.
Hope this helps!