I've only tried one pen colored with the Prismacolor markers. I used lacquer (air gun) on it, and it caused the colors to bleed. DCbluesman suggested I spray the lacquer onto a paper towel, then lighly dab it on the item to get a first sealing coat of lacquer on without it bleeding. Haven't yet done another pen so I haven't yet been able to try it.
Cheers,
Draken