I find that some acrylic blanks melt just a bit, especially when drilled a little too quickly. Some of the softened acrylic material can remain in the blank and stick to the insides of the blank, resulting in small irregularities inside the blank. The paint only adds to the issue. To prevent this from happening, I drill the blank, then I let it sit for a few moments to cool down and then I drill it again. The second quick pass through with the drill bit should remove any of these errant bits of acrylic that make the hole seem too small for the tube. Just one possible solution...
Jim Smith