Personally, I'm a CA fan when it comes to gluing tubes although I rarely use CA for finishing. I do have a few hints & tips to help avoid early setup, tube releasing & sticky fingers.
1. Use good quality glue. I've tried most of the available brands and have pretty much settled on the FastCap 2P-10 glue. It has a longer shelf time and flows better than most other types. You can buy it directly from FastCap or on Amazon, but I get mine from Mark Rawlings (Swagopenturner). He usually has some available for sale or trade.
2. Clean the drilled hole using dry compressed air, don't blow it out yourself - your breath moisture is a CA accelerant. Also let the freshly drilled blank set for a few minutes before gluing. Even slow drilling will heat the inside of the blank somewhat which is also an accelerant.
3. Test fit the drilled hole before gluing. You don't want a large gap, but you don't want it too snug either. If the tube doesn't slide in easily when it's dry, you'll likely have problems when it's covered with glue. Redrill with a bit that's 0.5mm to 1/32" larger if the hole is too small.
4. I mostly use medium CA glue, but I switch to thick when the humidity is up to get a little more working time. I make my own insertion tools from 1/2" delrin rod because I didn't like the tapers on the commercial tools (especially for 7mm and 8mm tubes).
5. I use a generous amount of glue, applying it all around the tube, then insert it into the blank using a twisting and in-out motion to coat the inside of the blank. Then I let it set at least overnight for good curing.
Personally, I don't have a problem with CA glue removing the paint from inside back-painted acrylic blanks. I use acrylic spray paint to coat the inside of my blanks and then let that cure for at least 2 days prior to gluing. The paint definitely needs to be fully cured, not just dry, when using CA glue.
Check out this video from Curtis Seebeck (mesquiteman) - it's the slickest CA-application technique that I've ever seen. So far, I haven't been able to duplicate it consistently, but I'm trying. The entire video is well worth watching, but you can skip ahead to about the 10:20 mark to watch him glue in the tube:
Mesquiteman on YouTube
As with all pen turning techniques, just keep experimenting until you find what works best for you.
Edgar