I think her grandmother is full Cherokee.
BTW....we do the Trail of Tears motorcycle ride every year. That is an awesome event
Did "we" include your friend???? If so what about something from that ride? Some landmark, or story perhaps? Something that you shared.
Blanket designs are fine in the generic sense, but these designs do have meaning and are very specific to every Indian Nation....
Best advise, be observant. What stories has she told you of her tribe, her clan, her history? Look around her house. Is there something there that you can get inspiration from? Failing that, look to the myths, legends and symbols of the Cherokee. (There are several) Maybe you can find something that resonates. Perhaps laser engrave the flag of the Cherokee Nation, on the wood and in the colors of her clan?? Maybe take her favourite Cherokee saying, or quote from a famous chief and have it in engraved in the Cherokee language??
What ever you choose, try to make it specific to her and her connection to her honorable heritage.